Q: Do we have to perform the CTA if the patient has a severely decreased kidney function?

A: This is a pragmatic trial and the safety of the patient is the most important. In case of an estimated eGFR <30 mL/min/1.73m2 it is okay to skip the CTA. However, we would like you to perform the NCCT.

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Q: Does the carotid ultrasound at 3 months have to be performed at the intervention center?

A: The carotid ultrasound should be performed at the intervention centre, seeing as payment (if the carotid echo is performed as part of research and not part of routine care!) is made to intervention center based on visits such as the carotid ultrasound. We will not be able to pay the referring center for the carotid ultrasound.

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Q: How do we have to complete the eCRF when a patient died?

A: If a patient dies, the upcoming visits may be reported as missing data. You do this by clicking on the 'wheel' to the right of a question, form or even entire visit and selecting the 'user missing' option. This way it is clear for the sponsor that follow-up was completed for this patient.

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Q: Should we report asymptomatic intracranial hemorrhages or EVT complications as AE’s?

A: Yes, you can do this by adding an (S)AE report in Castor.